Mostrando entradas con la etiqueta historia. Mostrar todas las entradas
Mostrando entradas con la etiqueta historia. Mostrar todas las entradas

noviembre 24, 2012

The Fleming Myth


Alexander Fleming realized the incredible medical of potential of penicillin when a stray mold spore landed on an exposed bacterial culture. Like so many great myths, this one has more than a grain (or mold spore) or truth to it. Scottish pharmacologist Sir Alexander Fleming did keep a notoriously messy lab, leaving bacterial cultures to pile up in a basin when he was finished with them. Mold could and did find its way into these abandoned cultures, including those of the Penicillium genus, which was being grown for other research purposes in another part of the building. Fleming did notice and identify the bacteria killing mold naming the substance it released "penicillin," which would go on to become one of medical science's great weapons. He was hardly the first to recognize its antibiotic properties, however.Penicillium was a known quantity, and many other researchers, including folks like Joseph Lister and Louis Pasteur, had noted its ability to kill bacteria. In 1929, though, Fleming published a paper in the British Journal of Experimental Pathology on the effects of penicillin on various bacteriological agents, noting that it could kill the bacteria without destroying living human tissue.
However, your grade school biology class might have treated this as a lightbulb moment, with Fleming immediately recognizing the potential of penicillin and whipping it into medical-grade shape. The truth was that Fleming didn't see penicillin as a particularly viable medicine. Douglas Allchin notes in his article "Scientific Myth-Conceptions," which appeared in the May 2003 issue of Science Education that Fleming was frustrated by penicillin's limitations. When taken orally, penicillin wasn't absorbed by the human body, and it was excreted quickly after being injected. Rather than investigate the therapeutic potential of penicillin, Fleming tended to goof around with penicillin, drawing pictures on culture plates using penicillin and bacteria, and eventually he abandoned his work on the mold. It was a different researcher, Oxford's Howard Florey, who would lead the charge to make penicillin into a viable method of treating human infection. Even as Florey and his associate, Sir Ernst Boris Chain, began reporting great results with penicillin as a potential therapeutic agent, Fleming did not turn his attention toward similar research. (In fact, when Fleming telephoned Florey to arrange a visit to their lab, Chain responded that he'd thought Fleming was dead.) Florey and Chain did share the 1945 Nobel Prize in medicine with Fleming, but it was Fleming who was named one of Time's 100 Persons of the Century. Florey and Chain have certainly been recognized as two of the great heroes of medical science, but they may never achieve the global fame Fleming earned for stumbling across penicillin in a dirty sink.
How did the story come about? Well, the half of this story that interests people most—that penicillin simply appeared one day on a bacterial culture—is true. But even Fleming himself termed his importance in the development of therapeutic penicillin the "Fleming Myth," and preferred to stress the importance of Florey and Chain's research. That myth, unsurprisingly, was started by the press. When Florey and Chain published their findings on the therapeutic uses of penicillin, they credited Fleming's article as their inspiration. Reporters loved the idea of this unknown, unsung Scottish researcher "discovering" penicillin by accident, and soon Fleming's name became synonymous with the life-saving drug.
Tomado de io9

abril 20, 2012

Epónimos mexicanos

Los epónimos ¿Qué mejor forma de hacer honor a alguien que ha dejado huella en el mundo de la medicina que bautizar una enfermedad con su nombre? Estrictamente hablando un epónimo es simplemente una palabra derivada del nombre de una persona, sin importar que ésta sea real o ficticia.

En la vida real los epónimos más que medallas de honor suelen ser una pesadilla para los estudiantes y el instrumento de tortura preferido de los cirujanos. Existen cientos de síndromes, signos, síntomas, instrumental, maniobras y clasificaciones con nombre propio, con los apellidos extravagantes de origen francés y germano dominando el panorama.

Hace poco un un profesor de cirugía mencionó que el primer requisito para que bautizaran una enfermedad con tu nombre era tener un apellido raro (con suerte algún día habrá un síndrome de Telich). No sé si sea algo obligatorio, pero lo que es un hecho es que los apellidos hispanos no aparecen muy seguido en los diccionarios de eponimia, y los mexicanos son aún más esporádicos.

En un afán por conocer la mayor cantidad de epónimos de origen mexicano he decidido crear una lista con los que conozco y algunos que he encontrado en internet. Incluye el nombre del síndrome/enfermedad/maniobra, su significado y una breve reseña del personaje homenajeado, espero lo disfruten y utilicen para apantallar a sus adscritos acalambradores. 

Epónimo Significado En honor a Más info
Índice de Cabrera Permite determinar crecimiento del ventrículo derecho en el ECG Enrique Cabrera Cossío, cardiólogo Bio en wikipedia
Signo de Cabrera Utilizado en el diagnóstico de IAM en presencia de bloqueo de rama izquierda del Haz de His. Manual de ECG
Índice de Lupi Cociente del diámetro de la rama derecha de la arteria pulmonar con el
diámetro del hemitórax ipsilateral en la tele de tórax
Eulo Lupi Herrera, cardiólogo Mini Bio
Complejo pulmonar de Chávez Signos clínicos de la hipertensión pulmonar: levantamiento sistólico del 2do EIC izq, cierre válvula pulmonar palpable, matidez cardiaca mayor a 2.5 cm por fuera del borde paraesternal izquierdo, reforzamiento pulmonar del segundo ruido y levantamiento paraesternal bajo. Ignacio Chávez Sánchez, cardiólogo y fundador del Instituto Nacional de Cardiología Bio en Wikipedia
Escala de Gómez Eescala para la clasificación de la desnutrición infantil. Federico Gómez Santos, pediatra, fundador del Hospital Infantil de México Biografía
Fórceps de Salas Salvador Salas Ceniceros, gineco-obstetra PubMed
Fórceps de Salinas Fórceps de ramas rectas con una leve curvatura pélvica Héctor Salinas, gineco-obstetra PubMed
Técnica de Fernández del Castillo Técnica de cerclaje para el cérvix uterino Carlos Fernández del Castillo, gineco-obstetra, fundador de la escuela de medicina de la Universidad Panamericana Ante la SCJN
Síndrome de Rivalcaba Conjunto de malformaciones esqueléticas de transmición autosómico recesiva; caracterizado por microcefalia, hipoplasia genital, retraso en el desarrollo físico y mental, talla baja, micrognatia y tórax en quilla Rogelio H. Ruvalcaba, pediatra Mini Bio
Síndrome de Ruvalcaba-Myhre-Smith Combina gigantismo cerebral con poliposis intestinal y presencia de manchas color café con leche en el penes
Maniobra de Rivero-Carvallo Aumento en la intensidad del soplo de insuficiencia tricuspídea durante la inspiración José Manuel Rivero Carvallo, cardiólogo Biografía
Reacción de Mazzotti Utilizada para el diagnóstico de la oncocercosis Luis Mazzotti Galindo, parasitólogo Mini Bio
Síndrome de Armendares Desorden caracterizado por talla baja, microcefalia, asimetría craneal, craneosinostosis y retinitis pigmentosa. Salvador Armendares Sagrera, pediatra y genetista Biografía

Como podrán darse cuenta los cardiólogos y los pediatras dominan el panorama. Sin duda producto de la proyección del Instituto Nacional de Cardiología y la cantidad de niños que hay en el país. Éstos son todos los que he podido conseguir hasta el momento, espero que la lista crezca con el paso del tiempo. Si conocen más epónimos de origen mexicano no duden en dejarlos como comentario y los agregaremos.

octubre 17, 2011

Palabras sabias de hombres sabios

Dr. Eduardo Liceaga
Les dejo algunas líneas que leí hoy en "Cirugía y Cirujanos". Son parte de discursos dados por un par de médicos mexicanos eminentes hace más de ochenta años, pero me parece que sus palabras deben impulsarnos tanto o más que a quienes tuvieron la oportunidad de escucharlos en vivo.

El primer extracto es del Dr. Eduardo Liceaga, en el discurso por la fundación del Hospital General de México el 5 de febrero de 1905:
Señores, para reivindicar nuestro puesto en el continente no necesitamos más que aplicar toda nuestra inteligencia, toda nuestra voluntad, a perfeccionarnos en el ramo que hemos elegido para ejercitar nuestra actividad. Éste es el contingente que debemos a nuestra patria. El país en donde cada hombre se empeña en perfeccionar la ciencia, el arte, la industria a que dedica si energía, ése país se hará grande, pues la suma de esas unidades activas forma parte de la nación.
El segundo es del maestro Ignacio Chávez, a quien durante todo este año de servicio social tendré muy presente en mi práctica diaria. 
El médico debe conservar el interés, el mismo aliento  generoso que lo ha sostenido en el pasado; el mismo espíritu de servicio sin el cual la profesión se convierte en una tarea, muy técnica si se quiere, pero deshumanizada. Esto no habrá de suceder si los médicos de hoy, compenetrados con el riesgo, lo neutralizan con la elevación moral de su conducta.
El haber escogido ser médico obliga a tener lealtad a su vocación y a su compromiso. A ser médico de verdad, pequeño o grande, no un forzado de su profesión que cumpla con su tarea con desgano y con irresposabilidad. Ser médico no entraña la obligación de ser sabio o figura eminente pero sí un profesional limpio, laborioso y merecedor de la confianza de sus enfermos y del respecto general. Ser médico implica la obligación consigo mismo de no frustrarse, de estudiar, de renovarse, de no caer en la mediocridad que lo empuja a la ineficacia; en todos términos procurar con ahínco su educación continua si ha de llevar con decoro la toga hipocrática. Si el médico ha de ser consejero, guía y figura respetada en el medio, está obligado a ensanchar la visión de su mundo y a buscar la comprensión de su tiempo, puliendo su cultura general.

febrero 03, 2011

Las vacunas, se llaman así ... precisamente por las vacas!!


La historia de la Medicina debate entre Edward Jenner y Lady Mary Montagu, el reconocimiento a la creación de las vacunas. Oficialmente se reconoce que fue el inglés, quien notó que las ordeñadoras de vacas, se conta
giaban de viruela solo en las manos, al entrar en contacto con la ubre infectada. Estas mujeres nunca desarrollaban una infección sistémica. Fue Jenner a quien se le ocurrió inyectar el contenido de una de las vesículas, en el brazo de un niño de 8 años llamado James Phipps, hijo de su jardinero. El niño, primera persona vacunada sobre la faz de la tierra, resistió la interacción con el virus. Así, nacían la vacunas, instrumento hoy injustamente temido por algunos, que constituye una expresión magistral, quizá la de mayor magistralidad, de la Medicina aplicada a la salud pública. Las VACUNAS, salvan vidas ... salvan las vidas de nuestros niños. La historia de las vacunas, otra de las muchas historias apasionantes escritas por los Médicos.

Del 19 al 25 de Febrero, 1º semana nacional de vacunación 2011.

agosto 30, 2010

The Art of Pimping

Me crucé por casualidad con esta joya publicada por el JAMA en 1989. En vista de que todos hemos vivido el pimping en carne propia y ahora los estudiantes que rotan conmigo me detestan por aplicarlo les comparto el siguiente texto:

THA ART OF PIMPING

by Frederick L. Brancati, MD, Department of Medicine, University of Pittsburgh.

From JAMA 262(1):89, July 7, 1989.

It's hard work becoming a revered attending physician in a university hospital. The task daunts the newly appointed junior attending as he strides down the corridor of his first ward with his first team. Oh, he's made some changes in anticipation of his new position. He's wearing a long coat now, an all-cotton coat with razor-sharp creases and knit buttons. The stained, shrunken polyester white pants and tennis shoes have given way to gray, light wool slacks with a cuff and polished loafers. Framed certificates bear testimony to his intelligence and determination. He should be ready to take the helm of his ward team, bu

t he's not. Something's missing, something important, something closer to art than to science. When physicians talk about the "art of medicine" they usually mean healing, or coping with uncertainty, or calculating their federal income taxes. But there's one art this new attending needs to learn before all others: the art of pimping.

Pimping occurs whenever an attending poses a series of very difficult questions to an intern or student. The earliest reference to pimping is attributed to Harvey in London in 1628. He laments his students' lack of enthusiasm for learning the circulation of the blood: "They know nothing of Natural Philosophy, these pin-heads. Drunkards, sloths, their bellies filled with Mead and Ale. O that I might see them pimped!"

In 1889, Koch recorded a series of "Puempfrage" or "pimp questions" he would later use on his rounds in Heidelberg. Unpublished notes made by Abraham Flexner on his visit to Johns Hopkins in 1916 yield the first American reference: "Rounded with Osler today. Riddles house officers with questions. Like a Gatling gun. Welch says students call it 'pimping.' Delightful."

On the surface, the aim of pimping appears to be Socratic instruction. The deeper motivation, however, is political. Proper pimping inculcates the intern with a profound and abiding respect for his attending physician while ridding the intern of needless self-esteem. Furthermore, after being pimped, he is drained of the desire to ask new questions -- questions that his attending may be unable to answer. In the heat of the pimp, the young intern is hammered and wrought into the framework of the ward team. Pimping welds the hierarchy of academics in place, so the edifice of medicine may be erected securely, generation upon generation. Of course, being hammered, wrought, and welded may, at times, be somewhat unpleasant for the intern. Still, he enjoys the attention and comes to equate his initial anguish with the aches and pains an athlete suffers during a period of intense conditioning.

Despite its long history and crucial importance in training, pimping as a medical art has received little attention from the educational establishment. A recent survey reveals that fewer than 1 in 20 attending physicians have had any formal training in pimping. In most American medical schools, pimping is covered haphazardly during the third-year medical clerkship or is relegated to a fourth-year elective. In a 1985 poll, over 95% of program directors admitted that the pimping skills of their trainees were "seriously inadequate." It comes as no surprise, then, that the newly appointed attending must teach himself how to pimp. It is to this most junior of attendings, therefore, that I offer the following brief guide to the art of pimping.

Pimp questions should come in rapid succession and should be essentially unanswerable. They may be grouped into five categories:

1. Arcane points of history. These facts are not taught in medical school and are irrelevant to patient care -- perfect for pimping. For example, who performed the first lumbar puncture? Or, how was syphilis named?

2. Teleology and metaphysics. These questions lie outside the realm of conventional scientific inquiry and have traditionally been addressed only by medieval philosophers and the editors of the National Enquirer. For instance, why are some organs paired?

3. Exceedingly broad questions. For example, what role do prostaglandins play in homeostasis? Or, what is the differential diagnosis of a fever of unknown origin? Even if the intern begins making good points, after 4 or 5 minutes he can be cut off and criticized for missing points he was about to mention. These questions are ideally posed in the final minutes of rounds while the team is charging down a noisy stairwell.

4. Eponyms. These questions are favored by many oldtimers who have assiduously avoided learning any new developments in medicine since the germ theory. For instance, where does one find the semilunar space of Traube? Or, whose name is given to the dancing uvula of aortic regurgitation?

5. Technical points of laboratory research. Even when general medical practice has become a dim and distant memory, the attending physician-investigator still knows the details of his research inside and out. For instance, how active are leukocyte-activated killer cells with or without interleukin 2 against sarcoma in the mouse model? Or, what base sequence does the restriction endonuclease EcoRI recognize?

Such pimping should do for the third-year student what the Senate hearings did for Robert Bork. The intern, in contrast, is a seasoned veteran and not so easily rattled. Years of relentless pimping have taught him two defenses: the dodge and the bluff.

Dodging avoids the question, wasting time as well as a valuable pimp question. The two most common forms of dodging are (1) to answer the question with a question and (2) to answer a different question. For example, the intern is asked to explain the pathophysiology of thrombosis secondary to the lupus anticoagulant. He first recites the clotting cascade, then recalls the details of a lupus case he admitted last month, and closes by asking whether pulse-dose steroids are indicated for lupus nephritis. The experienced attending immediately diagnoses this outpouring as a dodge, grabs the intern by the scruff of the neck, and rubs his nose back in the original pimp.

A bluff, unfortunately, is much more damaging than a dodge. Allowed to stand, a bluff promulgates a lie while undermining the academic hierarchy by suggesting that the intern has nothing more to learn from his attending. Bluffs weaken the very fabric of American medicine, threatening our livelihood and our way of life. Like outlaws in a Clint Eastwood movie, bluffs must be shot on sight -- no due process, no Miranda Act, no starry-eyed liberal notions of openness or dialogue -- just righteous retribution.

Bluffs fall into three readily discernible categories:

1. Hand waving. These bluffs are stock phrases that refer to hot topics in biomedicine without supplying detail or explanation. For example, "It's a membrane transport phenomenon" or "The effect is mediated by prostaglandins." In many institutions, they may evolve directly from the replies of Grand Rounds speakers to questions from the audience.

2. Feigned erudition. The intern's answer, though without substance, suggests an intimate understanding of the literature and a cautiousness born of experience. "Hmmm . . . to my knowledge, that question has not been examined in a prospective controlled fashion" is a common form. Frequently, the bluff is accompanied by three automatisms: clearing of the throat, rapid fluttering of the eyelids and tongue, and chewing on the temples of the eyeglasses. This triad, when full-blown, will make the intern bear a sudden resemblance to William Buckley and is virtually pathognomonic.

3. Higher authority. The intern attributes his answer to the teaching of a particular superior. When the answer is refuted, the blame of ignorance comes to rest on the higher authority, not on the obedient, accepting intern. The strength of the bluff depends on just whom is quoted. An intern quoting a junior resident about pathophysiology is every bit as cogent as Colonel Qaddafi quoting Ayatollah Khomeini about international law. An intern from an Ivy League medical school quoting the "training" he received on his medical clerkship goes over like Dan Quayle explaining the Bill of Rights at an ACLU convention. The shrewd intern, however, will quote his Chairman of Medicine or at least a division chief, pushing the nontenured attending to the brink of political calamity. Did the chairman actually say that? The attending is powerless to refute the statement until he is certain.

Indeed, a good bluff is hard to handle. Sometimes the intern's bluff sounds better to the ward team than the attending's correct answer. Sometimes it sounds better to the attending himself. Ultimately, the cunning intern is best discouraged from bluffing by aversive training. Specifically, each time he bluffs successfully, the attending should counter by inducing Sudden Intern Disgrace (SID). SID is induced in two ways:

1. Question the intern's ability to take a history. This technique depends on the phenomenon of historical drift. That is, a patient's story will reliably undergo a significant change in the 8- or 16-hour interval between admission and attending rounds. The attending need only go to the bedside and ask the same questions the intern did the night before. Now the entire case is seen in a light different than that cast by the intern's assessment. Yesterday's right upper quadrant cramping becomes right-sided pleuritic chest pain. Yesterday's ill-defined midepigastric "burning" becomes crushing substernal heaviness radiating to the arm and jaw. Suddenly, the intern is disgraced. He will never bluff again.

2. Question the intern's compulsiveness. In less rigorous programs, this is easy. Did the intern examine the peripheral blood smear and the urine sediment himself? If the intern does routinely examine body fluids, a more methodical approach is required. In this case, results of the following tests, procedures, and examinations may be requested in rapid succession: Hemoccult slide test, urine electrolytes, bedside cold agglutinins and serum viscosity, slit-lamp examination, Schiotz' tonometry, Gram's stain of the buffy coat, transtracheal aspiration, anoscopy, rigid sigmoidoscopy, and indirect laryngoscopy. Once the attending discovers a test or examination left unperformed, he asks the intern why this obviously crucial point was neglected. (The tension may be heightened at this point by frequent use of the word "cavalier.") The intern's response will generally revolve around time constraints and priorities in diagnostic evaluation. The attending's rejoinder: did the intern eat, sleep, or void last night? The scrupulous intern at once infers that he has placed his own needs before the needs of his patient. Suddenly, he is disgraced. He will never bluff again.

Clearly, pimping -- good pimping -- is an art. There are styles, approaches, and a few loose rules to guide the novice, but pimping is learned in practice, not theory. Despite its long and glorious history, pimping is in danger of becoming a lost art. Increased specialization, the rise of the HMO, and DRG-based financing are probably to blame, as they are for most problems. The burgeoning budget deficit, the changing demographic profile of the United States, the Carter Administration, inefficiency at the Pentagon, and intense competition from Japan have each played a role, though less directly. Against this mighty array of historical forces stands the beleaguered junior attending armed only with training, wit, and the determination to pimp. It won't be easy to turn back the clock and restore the art of pimping to its former grandeur. I only hope my guide will help.

mayo 24, 2010

Mixcoac, una visión decimonónica

Les dejo un relato sobre cómo era nuestro querido pueblo de Mixcoac durante el siglo XIX, cortesía de Ciudadanos en Red.

Mixcoac (Santo Domingo de), en la república de México, pueblo pequeño, situado a poco más de dos leguas de la capital, al S. O.

Su población es en la actualidad de unos 1,500 habitantes, repartidos, así en el casco del pueblo, como en varias huertas y barrios de sus alrededores. Son en su mayor parte indígenas, y se ocupan en la labranza de pequeñas suertes de tierra, que tienen ya en pro piedad, ya en enfiteusis.

Se cosecha una corta cantidad de maíz que se consume en el mismo pueblo, y se cogen varias frutas que se llevan a los mercados de la capital. Se ven también algunas magueyeras, siendo tlachique ó pulque dulce el que se saca de ellas.

Su única industria consiste en la fabricación del ladrillo, para la cual se cuentan hasta 10 hornos, siendo el que se elabora en este pueblo el más estimado de cuantos se introducen en la capital. Entre sus edificios es notable únicamente la casa del Lic. D. Francisco Molinos del Campo, por lo espacioso y sólido de su construcción. Es bella también la del señor magistrado D. Antonio Fernández Monjardin.

Si abundara el agua, Mixcoac seria mucho más ameno de lo que actual mente es. Sin embargo, crecen con notable lozanía los fresnos y chopos, y en algunos de sus barrios hay huertas y lugares deliciosos. Su iglesia, dedicada al santo que da su nombre al pueblo, nada tiene que llame la atención. Residen en el un párroco y un vicario.
En el orden político, pertenece a la prefectura de Tacubaya, y en el judicial al juzgado de letras ó de partidos de S. Angel. Hay en el pueblo un comisionado municipal y un juez de paz, para el des pacho y represión de los asuntos y delitos de poca importancia.

Aunque cuando Cortés se acerco a la capital, existía ya este pueblo, al cual da el conquistador en una de sus cartas al emperador Carlos V, el nombre de Mixquique, no conserva, sin embargo, ningún resto ni monumento de la época anterior a la conquista. Posteriormente, el único suceso notable, si así puede llamarse, acaecido en Mixcoac, es la mansión que hizo en él el presidente general Herrera y sus ministros, a su regreso de Querétaro, en 1848, al evacuar el ejército americano la capital, en virtud del Tratado de Guadalupe.
* La Ciudad de México y el D.F. 1824-1928, México, Instituto José Ma. Luis Mora 1988